ARAC Research Archive

Dr. Lance Price has been working on the antibiotic resistance crisis for nearly 20 years. Below is his entire portfolio of scientific discoveries related to antibiotic resistance.

General Bacterial Research

Combating Global Antibiotic Resistance: Emerging One Health Concerns in Lower- and Middle-Income CountriesClinical Infectious Diseases. Maya Nadimpalli, Elisabeth Delarocque-Astagneau, David C Love, Lance B Price, Bich-Tram Huynh, Jean-Marc Collard, Kruy Sun Lay, Laurence Borand, Awa Ndir, Timothy R Walsh, Didier Guillemot, January 2018.

Bacterial whack-a-mole: reconsidering the public health relevance of using carbadox in food animals. Price, LB. 2017. mBio: doi: 10.1128/mBio.01490-1726 September 2017 

Colonizing opportunistic pathogens (COPs): The beasts in all of us. Price LB, Hungate BA, Koch BJ, Davis GS, Liu CM (2017). PLoS Pathog 13(8): e1006369.

Phylogenetic organization of bacterial activity. ISME J. Morrissey EM, Mau RL, Schwartz E, Caporaso JG, Dijkstra P, van Gestel N, Koch BJ, Liu CM, Hayer M, McHugh TA, Marks JC, Price, LB, Hungate BA. 2016.

The Influence of Time and Plant Species on the Composition of the Decomposing Bacterial Community in a Stream Ecosystem. Microb Ecol. Wymore AS, Liu CM, Hungate BA, Schwartz E, Price, LB, Whitham TG, Marks JC. 2016 May.

Animal production and antimicrobial resistance in the clinic. Lancet. Robinson TP, Wertheim HFL, Kakkar M, Kariuki S, Bu D, Price, LB. 2016.

Clonal dissemination of Enterobacter cloacae harboring blaKPC-3 in the upper midwestern United States. Antimicrob Agents Chemother. Hargreaves ML, Shaw KM, Dobbins G, Vagnone PMS, Harper JE, Boxrud D, Lynfield R, Aziz M, Price, LB, Silverstein KAT, Danzeisen JL, Youmans B, Case K, Sreevatsan S, Johnson TJ. 2015.

Industrial food animal production and community health. Curr Environ Health Rep. Casey JA, Kim BF, Larsen J, Price, LB, Nachman KE. 2015.

A framework to reduce infectious disease risk from urban poultry in the United States. Public Health Rep. Tobin MR, Goldshear JL, Price, LB, Graham JP, Leibler JH. 2015.

Linking soil bacterial biodiversity and soil carbon stability. ISME J. Mau RL, Liu CM, Aziz M, Schwartz E, Dijkstra P, Marks JC, Price, LB, Keim P, Hungate BA. 2014 June 23.

Ominous projections for global antibiotic use in food animal productions (invited Commentary). Proc Nat Acad Sci. Price, LB, Koch BJ, Hungate BA. 2015 May 5.

Quantitative microbial ecology through stable isotope probing. Appl Environ Microbiol. Hungate BA, Mau RL, Schwartz E, Gregory Caporaso J, Dijkstra P, van Gestel N, Koch BJ, Liu CM, McHugh TA, Marks JC, Morrissey EM, Price, LB. 2015.

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota. Int Forum Allergy Rhinol. Liu CM, Kohanski MA, Mendiola M, Soldanova K, Dwan MG, Lester R, Nordstrom L, Price LB, Lane AP. 2015 Mar.

Community integrated omics links the dominance of a microbial generalist to fine-tuned resource usage. Nature Communications. Nat Commun. Wilmes P, Muller E, Nicolás P, Cedric L, Hoopmann M, Narayanasamy S, Lebrun L, Roume H, Lin J, May P, Hicks N, Heintz-Buschart A, Linda W, Liu C, Price LB, Gillece J, Guignard C, Schupp J, Vlassis N, Baliga N, Moritz R, and Keim P. 2014.

Genomics of an emerging clone of Salmonella serovar Typhimurium ST313 from Nigeria and the Democratic Republic of Congo. J Infect Dev Ctries. Leekitcharoenphon P, Friis C, Zankari E, Svendsen CA, Price LB, Rahmani M, Herrero-Fresno A, Fashae K, Vandenberg O, Aarestrup FM, Hendriksen RS. 2013 Oct 15.

Contrasting rRNA gene abundance patterns for aquatic fungi and bacteria in response to leaf-litter chemistry. Freshwater Sciences.Wymore AS, Compson ZG, Liu CM, Price LB, Whitham TG, Keim P, and Marks JC. 2013. 

An ecological perspective on U.S. industrial poultry production: the role of anthropogenic ecosystems on the emergence of drug-resistant bacteria from agricultural environments. Current Opinions in Microbiology. Davis MF, Price LB, Liu CM, Silbergeld E. 2011 Jun 14.

New infectious diseases and industrial food animal production. Emerg Infect Dis. Silbergeld E, Davis M, Feingold B, Goldberg A, Graham J, Leibler J, Peterson A, Price LB.2010.

No resistance plasmid in Yersinia pestis, North America. Emerg Infect Dis. Wagner DM, Runberg J, Vogler AJ, Lee J, Driebe E, Price LB, Engelthaler DM, Fricke WF, Ravel J, Keim P. 2010.

Fate of antimicrobial-resistant enterococci and staphylococci and resistance determinants in stored poultry litter. Environ Res. Graham JP, Evans SL, Price LB, Silbergeld. 2009.

Antibiotic resistant enterococci and staphylococci isolated from flies collected near confined poultry feeding operations. Sci Total Environ. Graham JP, Price LB, Evans SL, Graczyk TK, Silbergeld EK. 2009.

The Animal:Human Interface and Infectious Disease in Industrial Food Animal Production: Rethinking Biosecurity and Biocontainment. Public Health Reports. Graham, JP, Tuchmann JL, Price LB, Otte JM, Pfeiffer DU, Tiensin T, and Silbergeld EK. 2008.

Industrial Food Animal Production, Antimicrobial Resistance, and Human Health. Annu. Rev. Public Health. Silbergeld EK, Graham J, and Price LB. 2008.

Arsenic: a roadblock to potential animal waste management solutionsEnviron Health Perspect. Nachman, KE, Graham JP, Price LB and Silbergeld EK. 2005.


Prevalence of potentially neuropathic Campylobacter jejuni strains on commercial broiler chicken products. Int J Food Microbiol. Hardy CG, LackeyLG, CannonJ, Price LB, and Silbergeld EK. 2011.

The persistence of fluoroquinolone-resistant Campylobacter in poultry production. Environ Health Perspect. Price LB, Lackey L, Vailes R and Silbergeld E. 2007. 

Neurologic symptoms and neuropathologic antibodies in poultry workers exposed to Campylobacter jejuni. J Occ Environ Med. Price LB, Roess A, Graham JP, Baqar S, Vailes R, Sheikh KA, and Silbergeld E. 2007.

Arsenic Resistance in Campylobacter spp. Isolated from Retail Poultry Products. Appl Environ Microbiol. Chapin Sapkota AR, Price LB, Silbergeld EK and Schwab KJ. 2006.

Fluoroquinolone resistant Campylobacter from antibiotic-free and conventional poultry products. Environ Health Perspect. Price LB, Johnson E, Vailes R and Silbergeld E. 2005.

Escherichia coli (e coli)

Inactivation of transcriptional regulators during within-household evolution of Escherichia coli. J Bacteriol. Kisiela DI, Radey M, Paul S, Porter S, Polukhina K, Tchesnokova V, Shevchenko S, Chan D, Aziz M, Johnson TJ, Price, LB, Johnson JR, Sokurenko EV. 2017 Apr 24. 

Household Clustering of Escherichia coli Sequence Type 131 Clinical and Fecal Isolates According to Whole Genome Sequence Analysis. Open Forum Infect Dis. Johnson JR, Davis G, Clabots C, Johnston BD, Porter S, DebRoy C, Pomputius W, Ender PT, Cooperstock M, Slater BS, Banerjee R, Miller S, Kisiela D, Sokurenko EV, Aziz M, Price, LB. 2016 Jun 3.

Separate F-Type Plasmids Have Shaped the Evolution of the H30 Subclone of Escherichia coli Sequence Type 131. mSphere. Johnson TJ, Danzeisen JL, Youmans B, Case K, Llop K, Munoz-Aguayo J, Flores-Figueroa C, Aziz M, Stoesser N, Sokurenko E, Price, LB, Johnson JR. 2016 Jun 29.

Complete Genome Sequence of a CTX-M-15-Producing Escherichia coli Strain from the H30Rx Subclone of Sequence Type 131 from a Patient with Recurrent Urinary Tract Infections, Closely Related to a Lethal Urosepsis Isolate from the Patient's Sister. Genome Announc. Johnson TJ, Aziz M, Liu CM, Sokurenko E, Kisiela DI, Paul S, Andersen P, Johnson JR, Price, LB. 2016 May 12.

Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131. MBio. Stoesser N, Sheppard AE, Pankhurst L, de Maio N, Moore CE, Sebra R, Turner P, Anson LW, Kasarskis A, Batty EM, Kos V, Wilson DJ, Phetsouvanh R, Wyllie D, Sokurenko E, Manges AR, Johnson TJ, Price, LB, Peto TEA, Johnson JR, Didelot X, Sarah Walker A, Crook DW. 2016.

Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131. Antimicrob Agents Chemother. Johnson JR, Porter SB, Thuras P, Johnson TJ, Price, LB, Tchesnokova V, Sokurenko EV. 2015.

Prevalence of antibiotic-resistant E. coli in retail chicken: comparing conventional, organic, kosher, and raised without antibiotics. Version 2. Millman JM, Waits K, Grande H, Marks AR, Marks JC, Price LB, Hungate BA. 2013 Jul 11.

Epidemic clonal expansion of CTX-M-15-producing Escherichia coli ST131MBio. Price LB, JohnsonJR, AzizM, Clabots C, Johnston B, Tchesnokova V, Nordstrom L, Stegger M, Andersen PS, Pearson T, Keim P, and Sokurenko EV. 2013 Dec 17.

Complete Genome of the Epidemic and Highly Virulent CTX-M-15-Producing H30-Rx Subclone of Escherichia coli ST131. Genome Announcements. Andersen PS, Stegger M, Aziz M, Contente-Cuomo TC, Gibbons HS, Keim P, Sokurenko EV, Johnson JR, and Price LB. 2013 Dec 5.

Complete Genome Sequence of a Carbapenem-Resistant Extraintestinal Pathogenic Escherichia coli Strain Belonging to the Sequence Type 131 H30R Subclade. Genome Announc. Johnson TJ, Hargreaves M, Shaw K, Snippes P, Lynfield R, Aziz M, Price, LB. 2015 Apr 9.

Molecular Epidemiology of Escherichia coli Sequence Type ST131 and its H30 and H30-Rx Subclones Among Extended-Spectrum Beta-Lactamase-Positive and -Negative E. coli Clinical Isolates from the Chicago Region (2007-2010). Antimicrob Agents Chemother. Banerjee R, Robicsek A, Kuskowski MA, Porter S, Johnston BD, Sokurenko E, Tchesnokova V, Price LB, Johnson JR. 2013 Sep 30.

Predictive Diagnostics for Escherichia coli Infections Based on the Clonal Association of Antimicrobial Resistance and Clinical Outcome. J Clin Microbiol. Tchesnokova V, Billig M, Chattopadhyay S, Linardopoulou E, Aprikian P, Roberts PL, Skrivankova V, Johnston B, Gileva A, Igusheva I, Toland A, Riddell K, Rogers P, Qin X, Butler-Wu S, Cookson BT, Fang FC, Kahl B, Price LB, Weissman SJ, Limaye A, Scholes D, Johnson JR, Sokurenko EV. 2013 Sep.

Foodborne urinary tract infections (FUTIs): a new paradigm for antimicrobial-resistant foodborne illness. Front Microbiol. Nordstrom L, Liu CM, and Price LB. 2013.

Abrupt Emergence of a Single Dominant Multi-Drug-Resistant Strain of Escherichia coli. J Infect Dis. Johnson JR, Tchesnokova V, Johnston B, Clabots C, Roberts PL, Billig M, Riddell K, Rogers P, Qin X, Butler-Wu S, Price LB, Aziz M, Nicolas-Chanoine MH, Debroy C, Robicsek A, Hansen G, Urban C, Platell J, Trott D, Zhanel G, Weissman SJ, Cookson BT, Fang FC, Limaye A, Scholes D, Chattopadhyay S, Hooper DC, Sokurenko EV. 2013 Jan 3.

Role of Homologous Recombination in Adaptive Diversification of Extraintestinal Escherichia coli. J Bacteriol. Paul S, Linardopoulou EV, Billig M, Tchesnokova V, Price LB, Johnson JR, Chattopadhyay S, Sokurenko EV. 2013 Jan.

Elevated risk of carrying gentamicin-resistant Escherichia coli among US poultry workers. Environ Health Perspect. Price LB, Graham JP, Lackey L, Roess A, and Silbergeld E. 2007.

Klebsiella Pneumoniae

Recent Research Examining Links Among Klebsiella pneumoniae from Food, Food Animals, and Human Extraintestinal Infections. Curr Environ Health Rep. Davis GS, Price, LB. 2016 Jun 3.

Intermingled Klebsiella pneumoniae populations between retail meats and human urinary tract infections. Clin Infect Disease. Davis GS, Waits K, Nordstrom L, Weaver B, Aziz M, Gauld L, Grande H, Bigler R, Horwinski J, Porter S, Marc Stegger M, Johnson JR, Liu CM, Price, LB. 2015.

Methicillin-Resistant Staphylococcus Aureus (MRSA)

Drivers and Dynamics of Methicillin-Resistant Livestock-Associated Staphylococcus aureus CC398 in Pigs and Humans in Denmark. mBio. Raphael N. Sieber, Robert L. Skov, Jens Nielsen, Jana Schulz, Lance B. Price, Frank M. Aarestrup, Anders R. Larsen, Marc Stegger, Jesper Larsen. Nov 2018.

Emergence of livestock-associated methicillin-resistant Staphylococcus aureus bloodstream infections in Denmark. Clin Infect Dis. Larsen L,Petersen A, Larsen AR, Sieber RN,Stegger M, Koch A, Aarestrup FA, Price, LB, Skov RL, and the Danish MRSA Study Group. 2017 May 30.

Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus. Clin Infect Dis. Larsen J, Stegger M, Andersen PS, Petersen A, Larsen AR, Westh H, Agersø Y, Fetsch A, Kraushaar B, Käsbohrer A, Feβler AT, Schwarz S, Cuny C, Witte W, Butaye P, Denis O, Haenni M, Madec JY, Jouy E, Laurent F, Battisti A, Franco A, Alba P, Mammina C, Pantosti A, Monaco M, Wagenaar JA, de Boer E, van Duijkeren E, Heck M, Domínguez L, Torres C, Zarazaga M, Price, LB, Skov RL. 2016 Nov 15.

Meticillin-resistant Staphylococcus aureus CC398 is an increasing cause of disease in people with no livestock contact in Denmark, 1999 to 2011. Euro Surveill. Larsen J, Petersen A, Soerum M, Stegger M, van Alphen L, Valentiner-Branth P, Knudsen LK, Larsen LS, Feingold B, Price, LB, Andersen PS, Larsen AR, Skov RL. 2015.

Origin and evolution of European community-acquired methicillin-resistant Staphylococcus aureus. MBio. Stegger M, Wirth T, Andersen PS, Skov RL, De Grassi A, Simões PM, Tristan A, Petersen A, Aziz M, Kiil K, Cirković I, Udo EE, del Campo R, Vuopio-Varkila J, Ahmad N, Tokajian S, Peters G, Schaumburg F, Olsson-Liljequist B, Givskov M, Driebe EE, Vigh HE, Shittu A, Ramdani-Bougessa N, Rasigade JP, Price LB, Vandenesch F, Larsen AR, Laurent F. 2014 Aug 26.

A case control study of environmental and occupational exposures associated with methicillin resistant Staphylococcus aureus nasal carriage in patients admitted to a rural tertiary care hospital in a high density swine region. Environ Health. Schinasi L, Wing S, L Augustino K, Ramsey KM, Nobles DL, Richardson DB, Price LB, Aziz M, MacDonald PD, Stewart JR. 2014 Jun 23.

Multidrug-resistant and methicillin-resistant Staphylococcus aureus (MRSA) in hog slaughter and processing plant workers and their community in North Carolina (USA). Environ Health Perspect. Neyra RC, Frisancho JA, Rinsky JL, Resnick C, Carroll KC, Rule AM, Ross T, You Y, Price LB, Silbergeld EK. 2014 May;122(5):471-7. doi: 10.1289/ehp.1306741.

Livestock-associated methicillin and multidrug resistant Staphylococcus aureus is present among industrial, not antibiotic-free livestock operation workers in North Carolina. PLoS One. Rinsky JL, Nadimpalli M, Wing S, Hall D, Baron D, Price LB, Larsen J, Stegger M, Stewart J, Heaney CD. 2013 Jul 2.

Molecular and phenotypic characteristics of health care- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) at a tertiary care center in Pennsylvania, 2009-2010. PLoS One. Peterson AE, Davis MF, Awantang G, Julian KG, Greene WH, Doppalapudi A, Price LB, Waters A, Krain LJ, Nelson LJ, Silbergeld EK, Whitener CJ. 2012.

Genome Sequence of Staphylococcus aureus Strain 11819-97, an ST80-IV European Community-Acquired Methicillin-Resistant isolate. J. Bacteriol. Stegger M, Price LB, Larsen A, Gillece JG, Waters AE, Skov R, and Andersen PS. 2012.

Dry collection and culture methods for recovery of methicillin-susceptible and methicillin-resistant Staphylococcus aureus from indoor home environments. Appl Environ Microbiol. Davis MF, Baron P, Price LB, Williams D, Jeyaseelan S, Hambleton I, Diette GB, Breysse PN, McCormack MC.2012 Jan 27.

Staphylococcus Aureus

Whole-Genome Analysis of Recurrent Staphylococcus aureua t571/ST398 Infection in Farmer, Iowa, USAEmerging Infectious Diseases. Shylo E. Wardyn, Marc Stegger, Lance B. Price, and Tara C. Smith. 2018.

Staphylococcus aureus nasal carriage among beefpacking workers in a midwestern united states slaughterhouse. PLoS ONE. Leibler JH, Jordan JA, Brownstein K, Lander L, Price, LB, Perry MJ. 2016.

Using Whole Genome Analysis to Examine Recombination across Diverse Sequence Types of Staphylococcus aureus. PLoS One. Driebe EM, Sahl JW, Roe C, Bowers JR, Schupp JM, Gillece JD, Kelley E, Price LB, Pearson TR, Hepp CM, Brzoska PM, Cummings CA, Furtado MR, Andersen PS, Stegger M, Engelthaler DM, Keim PS. 2015 Jul 10.

Staphylococcus aureus and the Ecology of the Nasal Microbiome. Science Advances. Liu CM, Price, LB, Hungate, BA, Abraham A, Larsen LA, Christensen K, Stegger M, SkovR, Andersen PS. 2015 June 5.

Rapid differentiation between livestock-associated and livestock-independent Staphylococcus aureus CC398 clades. PLoS One. Stegger M, Liu CM, Larsen J, Soldanova K, Aziz M, Contente-Cuomo T, Petersen A, Vandendriessche S, Jiménez JN, Mammina C, van Belkum A, Salmenlinna S, Laurent F, Skov RL, Larsen AR, Paal S. Andersen PS, and Price LB. 2013 Nov 14.

Genome analysis of Staphylococcus aureus ST291, a double locus variant of ST398, reveals a distinct genetic lineage. PLoS One. Stegger M, Aziz M, Chroboczek T, Price LB, Ronco T, Kiil K, Skov RL, Laurent F, Andersen PS. 2013 May 21.

Household risk factors for colonization with multidrug-resistant Staphylococcus aureus isolates. PLoS One. Davis MF, Peterson AE, Julian KG, Greene WH, Price LB, Nelson K, Whitener CJ, Silbergeld EK. 2013.

Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock. MBio. Price LB, Stegger M, Hasman H, Aziz M, Larsen J, Andersen PS, Pearson T, Waters AE, Foster JT, Schupp J, Gillece JG, Driebe E, Liu CM, Springer B, Zdovc I, Battisti A, Franco AF, Żmudzki J, Schwarz S, Butaye P, Jouy E, Pomba C, Porrero C, Ruimy R, Smith TC, Robinson A, Weese S, Arriola CS, Yu F, Laurent F, Keim P, Skov R, and Aarestrup F. 2012 Feb 21.

Multidrug Resistant Staphylococcus aureus in US Meat and Poultry: Evidence for animal origins. Clin Infect Dis. Waters A, Contente-Cuomo T, Buchhagen J, Liu CM, Watson L, Pearce K, Foster JT, Bowers J, Driebe E, Engelthaler D, Keim PS, Price LB. 2011.